Open Daily: 10am - 10pm | Alley door pickup 10am - 7pm 3038 Hennepin Ave Minneapolis, MN
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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Leptin: Physiology and Biological Functions

Leptin: Physiology and Biological Functions

El-Banna, Mona
Hassan, Heba

Paperback

Biology

ISBN10: 6630118383
ISBN13: 9786630118384
Publisher: Scholars' Press
Published: Oct 6 2026
Pages: 96
Weight: 0.31
Height: 0.23 Width: 6.00 Depth: 9.00
Language: English
Leptin is a multifunctional adipocyte-derived hormone that plays a central role in energy homeostasis, appetite, food intake, energy expenditure, and body weight regulation through leptin receptor-mediated signaling in the brain and peripheral tissues. Its actions involve several signaling pathways, including JAK/STAT, PI3K, MAPK, and AMPK. Beyond energy regulation, leptin contributes to brain and neuroendocrine functions, glucose and lipid metabolism, insulin sensitivity, reproduction, immune regulation, and skeletal homeostasis. It influences bone remodeling, osteoblast and chondrocyte function, and cartilage metabolism, highlighting the close interaction between adipose tissue and other physiological systems. Dysregulated leptin signaling, particularly leptin resistance, is strongly associated with obesity and metabolic disturbances. Overall, knowledge of leptin physiology and its diverse biological functions provides an essential basis for examining the consequences of impaired leptin signaling in metabolic and other chronic disorders.

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