Open Daily: 10am - 10pm | Alley door pickup 10am - 7pm 3038 Hennepin Ave Minneapolis, MN
612-822-4611

  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Mechanisms, Risk Factors, and Treatment Strategies for Osteoporosis

Mechanisms, Risk Factors, and Treatment Strategies for Osteoporosis

El-Banna, Mona

Paperback

Biology

ISBN10: 6208429102
ISBN13: 9786208429102
Publisher: LAP Lambert Academic Publishing
Published: Feb 10 2025
Pages: 88
Weight: 0.28
Height: 0.21 Width: 6.00 Depth: 9.00
Language: English
Osteoporosis is a systemic skeletal disorder characterized by reduced bone mass and microarchitectural deterioration, leading to increased fracture risk. Multiple factors contribute to its pathogenesis, including hormonal deficiencies (estrogen, testosterone, and growth hormone), metabolic imbalances, chronic inflammation, glucocorticoid therapy, and lifestyle-related influences. Glucocorticoids (GCs) play a significant role in osteoporosis by inhibiting osteoblast differentiation, promoting osteoclast activity via the RANKL-OPG pathway, impairing calcium absorption, and disrupting vitamin D metabolism. Additionally, inflammatory cytokines, growth factors, and prostanoids influence bone remodeling, further exacerbating bone loss. Management strategies include lifestyle modifications, adequate calcium and vitamin D intake, pharmacologic interventions (bisphosphonates, SERMs, PTH analogs, and monoclonal antibodies), and hormone replacement therapy where applicable. Early detection and intervention are essential to prevent fractures and maintain skeletal health.

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