Open Daily: 10am - 10pm | Alley door pickup 10am - 7pm 3038 Hennepin Ave Minneapolis, MN
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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Insulin Resistance: Mechanisms, and Disease Susceptibility

Insulin Resistance: Mechanisms, and Disease Susceptibility

El-Banna, Mona
Hassan, Heba
Hussein, Jihan

Paperback

Biology

ISBN10: 6202353627
ISBN13: 9786202353625
Publisher: Scholars' Press
Published: Feb 16 2026
Pages: 120
Weight: 0.38
Height: 0.28 Width: 6.00 Depth: 9.00
Language: English
Insulin resistance is characterized by a reduced cellular response to insulin, mainly due to impaired glucose uptake, diminished glycogen synthesis, and altered glucose metabolism. It predominantly affects skeletal muscle, adipose tissue, and liver, leading to disrupted glucose and lipid homeostasis. Skeletal muscle shows reduced glucose disposal, adipose tissue exhibits increased lipolysis and inflammatory mediator release, and the liver demonstrates impaired glucose suppression with enhanced lipid accumulation and VLDL secretion. Insulin resistance also compromises endothelial function by reducing nitric oxide bioavailability and promoting pro-atherogenic signaling through selective impairment of the PI3K pathway, contributing to vascular dysfunction and atherosclerosis.

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