Open Daily: 10am - 10pm | Alley door pickup 10am - 7pm 3038 Hennepin Ave Minneapolis, MN
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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Endothelial Dysfunction: Mechanisms and Clinical Impact

Endothelial Dysfunction: Mechanisms and Clinical Impact

El-Banna, Mona
Hassan, Heba

Paperback

Biology

ISBN10: 663032708X
ISBN13: 9786630327083
Publisher: Scholars' Press
Published: Aug 10 2026
Pages: 128
Weight: 0.40
Height: 0.30 Width: 6.00 Depth: 9.00
Language: English
Endothelial cells form a specialized monolayer lining the interior of blood and lymphatic vessels and play a central role in maintaining vascular homeostasis. They regulate vascular tone, permeability, hemostasis, angiogenesis, inflammation, immune cell trafficking, and tissue repair through the balanced production of vasoactive mediators and signaling molecules. Disruption of these functions leads to endothelial dysfunction, a key event in the development of numerous chronic diseases. Oxidative stress, characterized by excessive ROS production, together with chronic inflammation, impairs endothelial function by reducing nitric oxide bioavailability, promoting vascular remodeling, thrombosis, and inflammatory activation. These alterations contribute to the pathogenesis of atherosclerosis and are implicated in cardiovascular diseases, hypertension, diabetes mellitus, obesity, chronic kidney disease, inflammatory bowel disease, osteoporosis, chronic obstructive pulmonary disease, cancer, and Alzheimer's disease. This book presents an overview of endothelial cell biology, the molecular mechanisms of endothelial dysfunction, and the interplay between oxidative stress and inflammation.

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