Open Daily: 10am - 10pm | Alley door pickup 10am - 7pm 3038 Hennepin Ave Minneapolis, MN
612-822-4611

  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Epilepsy: Genetics, Biomarkers, and advances toward Precision Medicine

Epilepsy: Genetics, Biomarkers, and advances toward Precision Medicine

El-Banna, Mona

Paperback

Biology

ISBN10: 6209132251
ISBN13: 9786209132254
Publisher: LAP Lambert Academic Publishing
Published: Nov 7 2025
Pages: 88
Weight: 0.28
Height: 0.21 Width: 6.00 Depth: 9.00
Language: English
Epilepsy is a heterogeneous neurological disorder characterized by recurrent, unprovoked seizures, with nearly one-third of patients remaining resistant to current therapies. Its multifactorial basis involves genetic, molecular, epigenetic, inflammatory, and metabolic contributors that drive disease heterogeneity. Genetic modifiers such as ion channel mutations (SCN1A, GABRA1, CHRNA4) and mTOR pathway disruptions (TSC1, DEPDC5), along with epigenetic mechanisms linking environmental influences to gene expression, play central roles in seizure susceptibility and treatment response. A broad spectrum of biomarkers-genetic, proteomic, metabolomic, imaging, and electrophysiological-provides critical insights for diagnosis, prognosis, and therapeutic strategies. Integrating molecular discoveries with clinical perspectives underscores the potential of biomarker-driven precision medicine, supporting targeted therapies, optimized patient stratification, and improved long-term outcomes in epilepsy.

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