Open Daily: 10am - 10pm | Alley door pickup 10am - 7pm 3038 Hennepin Ave Minneapolis, MN
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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Parkinson's Disease: Insights into Pathogenesis and Symptomatology

Parkinson's Disease: Insights into Pathogenesis and Symptomatology

El-Banna, Mona

Paperback

Biology

ISBN10: 3639714113
ISBN13: 9783639714111
Publisher: Scholars' Press
Published: Jan 15 2025
Pages: 72
Weight: 0.24
Height: 0.17 Width: 6.00 Depth: 9.00
Language: English
Parkinson's disease (PD) is a common neurodegenerative disorder affecting over 10 million people worldwide, with prevalence rising with age. It is characterized by motor symptoms like bradykinesia and rigidity, and non-motor symptoms driven by dopaminergic neuron loss in the substantia nigra pars compacta (SNpc). Key pathological features include alpha-synuclein aggregation into Lewy bodies, mitochondrial dysfunction, oxidative stress, and neuroinflammation.As PD progresses, dopamine depletion worsens, leading to advanced motor complications and non-motor impairments. Current treatments alleviate symptoms but do not prevent neurodegeneration. Understanding the mechanisms of alpha-synuclein aggregation, mitochondrial dysfunction, and neuroinflammation is essential for developing effective disease-modifying therapies.

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