Open Daily: 10am - 10pm | Alley door pickup 10am - 7pm 3038 Hennepin Ave Minneapolis, MN
612-822-4611

  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Hepatocellular Carcinoma Etiology and Molecular Signaling

Hepatocellular Carcinoma Etiology and Molecular Signaling

Hassan, Heba
El-Banna, Mona

Paperback

Biology

ISBN10: 6209954189
ISBN13: 9786209954184
Publisher: LAP Lambert Academic Publishing
Published: Jun 30 2026
Pages: 88
Weight: 0.28
Height: 0.21 Width: 6.00 Depth: 9.00
Language: English
Hepatocellular carcinoma (HCC) is the most common primary liver cancer and a major cause of cancer-related mortality worldwide. It develops mainly in response to chronic liver injury caused by hepatitis B and C virus infections, alcohol abuse, metabolic dysfunction-associated steatotic liver disease (MASLD), aflatoxin exposure, and hereditary metabolic disorders. Persistent inflammation promotes oxidative stress, hepatocyte injury, and activation of hepatic stellate cells, leading to fibrosis and cirrhosis, the principal risk factor for HCC. The cirrhotic liver creates a tumor-promoting microenvironment characterized by continuous tissue injury, regeneration, hypoxia, and genomic instability. HCC progression is further driven by dysregulation of key signaling pathways, including Wnt/β-catenin, PI3K/Akt/mTOR, MAPK, JAK/STAT, and TGF-β, which regulate cell proliferation, survival, angiogenesis, invasion, and metastasis. Understanding the interactions among chronic inflammation, fibrosis, cirrhosis, and molecular signaling is essential for identifying biomarkers and developing effective strategies for HCC prevention, early diagnosis, and targeted therapy.

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