Sign-In
Cart
Transcription Factors and Human Genetic Disease
Hardcover
Series: Oxford Monographs on Medical Genetics, Book 37
Health GeneralMedical Reference
Please select the version of book you would like to purchase.
ISBN10: 0195112393
ISBN13: 9780195112399
Publisher: Oxford University Press
Published: Oct 1 1998
Pages: 384
Weight: 2.00
Height: 0.99 Width: 6.52 Depth: 9.40
Language: English
ISBN13: 9780195112399
Publisher: Oxford University Press
Published: Oct 1 1998
Pages: 384
Weight: 2.00
Height: 0.99 Width: 6.52 Depth: 9.40
Language: English
Several general principles have emerged from the study of human transcription factors. First, germline mutations in genes encoding transcription factors result in malformation syndromes in which the development of multiple body structures is affected. Second, somatic mutations involving many of the same genes contribute to tumorigenesis. Third, transcriptional regulatory mechanisms demonstrate remarkable evolutionary conservation. Fourth, prenatal development and postnatal physiology are unified by the demonstration that a single transription factor can control the proliferation of progenitor cells during development and the expression within the differentiated cells of gene products that participate in specific physiologic responses.
Transcription Factors and Human Disease presents the basic science of transcriptional regulation and then describes inherited human diseases attributable to mutations in DNA sequences encoding transcription factors or their cognate binding sites. The involvement of transcription factors in somatic cell genetic diseases (cancer) and epigenetic disease (teratogenesis) is briefly discussed. The effect of specific mutations on transcription factor activity and the relationship between transcriptional dysregulation, dominant or recessive inheritance patterns, and disease pathogenesis are also explored. This book thus provides a direct connection between molecular defects in transcriptional regulation and human pathophysiology.
Also in
Health General
The Tao of Immortality: The Four Healing Arts and the Nine Levels of Alchemy
Wei, William U.
Chia, Mantak
Paperback
$37.95
Cosmic Health: Unlock Your Healing Magic with Astrology, Positive Psychology, and Integrative Wellness
Racioppi, Jennifer
Hardcover
$10.99
The Adventurous Eaters Club: Mastering the Art of Family Mealtime
Collins, Misha
Collins, Vicki
Hardcover
$14.99
The Healthy Deviant: A Rule Breaker's Guide to Being Healthy in an Unhealthy World
Gerasimo, Pilar
Paperback
From $11.99
Wheat Belly: Lose the Wheat, Lose the Weight, and Find Your Path Back to Health
Davis, William
Hardcover
$9.99
Essential Oils for the Whole Body: The Dynamics of Topical Application and Absorption
Godfrey, Heather Dawn
Paperback
$23.74
The Healing Power of the Mind: Practical Techniques for Health and Empowerment
Alexander, Rolf
Paperback
$12.30
Being Well (Even When You're Sick): Mindfulness Practices for People with Cancer and Other Serious Illnesses
Rosenbaum, Elana
Paperback
From $4.98
The Blue Zone: Lessons for Living Longer from the People Who've Lived the Longest
Buettner, Dan
Hardcover
$11.99
All about Allergies: Everything You Need to Know about Asthma, Food Allergies, Hay Fever, and More
Rubin, Zachary, MD
Hardcover
$27.00
Body Electric: The Hidden Health Costs of the Digital Age and New Science to Reclaim Your Well-Being
Zomorodi, Manoush
Diaz, Keith
Hardcover
$28.49
Nourishing Traditions: The Cookbook That Challenges Politically Correct Nutrition and the Diet Dictocrats
Enig, Mary
Fallon, Sally
Paperback
From $19.99
Dopamine Kids: A Science-Based Plan to Rewire Your Child's Brain and Take Back Your Family in the Age of Screens and Ultraprocessed Foods
Doucleff, Michaeleen
Hardcover
$27.00
10-Minute Chair Yoga Exercises for Seniors: 40 Poses to Build Strength and Flexibility for Fall Prevention
Hattori, April
Paperback
$14.24
Enough: Your Health, Your Weight, and What It's Like to Be Free
Jastreboff, Ania M.
Winfrey, Oprah
Hardcover
$28.50
Holy Health: Habits and Rhythms to Heal Your Body and Transform Your Life
Roethlingshoefer, Justin
Hardcover
$37.49
Rosemary Gladstar's Medicinal Herbs: A Beginner's Guide: 33 Healing Herbs to Know, Grow, and Use
Gladstar, Rosemary
Paperback
$16.14
You've Been Pooping All Wrong: How to Make Your Bowel Movements a Joy
Pasricha, Trisha, MD MPH
Hardcover
$28.50
Weightless: A Doctor's Guide to Glp-1 Medications, Sustainable Weight Loss, and the Health You Deserve
Salas-Whalen, Rocio, MD
Hardcover
$27.55
Fed Up: What Evolution Reveals about Food, Diet, Health, and Eating Well
Lieberman, Daniel E.
Hardcover
$31.50
Brain Defenders: Harness the Power of Your Immune Cells to Protect Your Brain for Life
Perlmutter, David, M. D.
Hardcover
$30.40
The Invincible Brain: The Clinically Proven Plan to Age-Proof Your Brain and Stay Sharp for Life
Fotuhi, Majid
Hardcover
$30.40
The Biblio Diet: Live Long, Master Metabolism, Reduce Pain, Fight Depression, and Conquer Cancer with Healing Secrets from the Bible
Axe, Josh
Rubin, Jordan
Hardcover
$28.50
The 30-Day Mediterranean Meal Plan and Cookbook: A Beginner's Guide to the World's Best Diet for Long-Term Health and Longevity
Zozos, Alexandria
Paperback
$23.74
Heal Your Cells: Reversing the Irreversible--A Proven Plan to Heal Faster, Reclaim Energy, and Unlock Longevity
Cole, Will
Axe, Josh
Hardcover
$30.40
Mayo Clinic Guide to a Healthy, Happy Heart: Simple Steps to Achieving Long-Term Cardiovascular Health
Lara-Breitinger, Kyla M.
Lopez-Jimenez, Francisco
Lerman, Amir
Hardcover
$26.09
The Stimulated Mind: Future-Proof Your Brain from Dementia and Stay Sharp at Any Age
Wood, Tommy
Hardcover
$31.35
The Thyroid Fix: The No-Nonsense Guide to Fix Fatigue, Fogginess, and Fat That Won't Budge
Hornaman, Amie
Hardcover
$28.50
What to Eat Now: The Indispensable Guide to Good Food, How to Find It, and Why It Matters
Nestle, Marion
Hardcover
From $19.99
How Not to Die: Revised and Updated: Discover the Foods Scientifically Proven to Prevent and Reverse Disease
Stone, Gene
Greger, Michael
Hardcover
$35.14
The Ultimate Survival Medicine Guide: Emergency Preparedness for Any Disaster
Alton, Amy
Alton, Joseph
Paperback
$18.99
The Hormone Loop: An Empowering Guide to Restoring Hormonal Harmony, from Puberty to Menopause
Goddard, Gillian
Hardcover
$28.50
Mayo Clinic Guide to Arthritis, Revised and Updated: Managing Joint Pain for an Active Life
Arment, Courtney A.
Hardcover
$27.00
Why We Get Sick: The Hidden Epidemic at the Root of Most Chronic Disease--And How to Fight It
Bikman, Benjamin
Paperback
From $11.99
Ibs: Finding and Treating the Root Cause of Irritable Bowel Syndrome
Wentz, Izabella, Pharmd
Hardcover
$30.40
Fast Like a Girl: A Woman's Guide to Using the Healing Power of Fasting to Burn Fat, Boost Energy, and Balance Hormones
Pelz, Mindy
Hardcover
From $12.99
100 No-Equipment Workouts Vol. 1: Easy to Follow Home Workouts Suitable for all Fitness Levels
Rey, Neila
Paperback
$20.99
Independence for Life: The Complete Guide to Building Strength and Regaining Mobility Beyond 50
Harlow, Will
Paperback
$25.64
The Way Out: A Revolutionary, Scientifically Proven Approach to Healing Chronic Pain
Gordon, Alan
Ziv, Alon
Paperback
$19.00
Stay Off My Kitchen Table: A Heart Surgeon's 4-Week Elimination Diet for Gut Repair, Metabolic Health, and Longevity
Ovadia, Philip
Lisec, Joshua
Paperback
$28.45
The Comfort Crisis: Embrace Discomfort to Reclaim Your Wild, Happy, Healthy Self
Easter, Michael
Hardcover
From $12.99
The Obesity Code: Unlocking the Secrets of Weight Loss (Why Intermittent Fasting Is the Key to Controlling Your Weight)
Fung, Jason
Paperback
From $10.99
What Your Doctor Doesn't Know about Fibromyalgia: Why Doctors Can't or Won't Treat Chronic Pain
Meilink, Linda
Rhoades, Patrick
Paperback
$15.15
Eight Million Ways to Happiness: Wisdom for Inspiration and Healing from the Heart of Japan
Yoda, Hiroko
Hardcover
$26.10
Long Life Yoga: Essential Practices for Longevity, Well-Being, and Joy at Any Age
Lee, Cyndi
Hardcover
$22.46
Histamine Haven: The Essential Guide and Cookbook to Histamine and Mast Cell Activation
Tracey Reed
Luka Symons
Paperback
$33.24
The Well-Lived Life: A 102-Year-Old Doctor's Six Secrets to Health and Happiness at Every Age
McGarey, Gladys
Hardcover
$14.99
Good Energy: The Surprising Connection Between Metabolism and Limitless Health
Means, Calley
Means, Casey
Hardcover
From $17.99
Feeding Littles Lunches: 75+ No-Stress Lunches Everyone Will Love: Meal Planning for Kids
McNamee, Megan, MPH Rdn
Delaware, Judy, Otr/L CLC
Paperback
$25.64
Mayo Clinic on Alzheimer's Disease and Other Dementias, Revised and Updated: A Guide for People with Dementia and Those Who Care for Them
Lunde, Angela
Graff-Radford, Jonathan
Hardcover
$27.00
Prevent and Reverse Heart Disease: The Revolutionary, Scientifically Proven, Nutrition-Based Cure
Esselstyn, Caldwell B.
Paperback
From $11.99
Longevity...Simplified: Living A Longer, Healthier Life Shouldn't Be Complicated
Luks, Howard J.
Hardcover
$28.49
The Essential Home Apothecary Handbook: Herbal Remedies to Know, Grow, Make, and Use
Reppert-Brill, Susanna
Sams, Tina
Hardcover
$23.74
Push: Unlock the Science of Fitness Motivation to Embrace Health and Longevity
Metzl, Jordan D., MD
Metzl, Jordan D., MD
Paperback
$19.95
Some Secrets Should Never Be Kept: Protect children from unsafe touch by teaching them to always speak up
Sanders, Jayneen
Paperback
$13.69
Hidden Epidemic: Silent Oral Infections Cause Most Heart Attacks and Breast Cancers
Levy, Jd
Paperback
$37.44
Move, Thrive, and Come Alive: Over 120 Science-Backed Strategies to Move More, Feel Better, and Live Fully
Gonzalez, Kyle
Paperback
$20.90
Bottle Service: Education and Encouragement for Guilt-Free and Successful Formula Feeding
Whitmore, Mallory
Paperback
$17.10
Fit Baby, Smart Baby, Your Baby!: From Birth to Age Six
Doman, Glenn
Doman, Douglas
Hagy, Bruce
Paperback
$18.95
Indoor Epidemic: 93% Inside Steals Sleep, Focus & Years-The 7% Outdoor Rx Restores Them
La Puma, John
Paperback
$18.99
The Whole Truth: The Hidden Agendas Behind Decades of Health Misinformation--And What to Do about It
Campbell, Nelson
Campbell, T. Colin
Hardcover
$26.55
Kiss Your Dentist Goodbye: A Do-It-Yourself Mouth Care System for Healthy, Clean Gums and Teeth
Phillips, Ellie
Paperback
$18.00
Genderqueer Menopause: Navigating Menopause for Trans, Gender-Nonconforming, Genderfluid, and Other Queer-Bodied Folx
Firefox Allen, Lasara, MSW
Paperback
$19.90
The Everything Easy Mind Diet Cookbook: 175 Delicious Recipes to Combat Dementia, Improve Cognitive Function, and Support Overall Health
Ellingsworth, Christy
Paperback
$18.05
Super Gut: A Four-Week Plan to Reprogram Your Microbiome, Restore Health, and Lose Weight
Davis, William
Paperback
From $12.99
Super Body: A 3-Week Program to Harness the New Science of Body Composition and Restore Your Youthful Contours
Davis, William
Hardcover
$28.50
The Biblio Diet Study Guide: Live Long, Master Metabolism, Reduce Pain, Fight Depression, and Conquer Cancer with Healing Secrets from the Bible
Rubin, Jordan
Axe, Josh
Paperback
$16.14
Aligned: The Data-Driven Guide to Performance, Recovery, and Human Potential
Holmes, Kristen, PhD
Hardcover
$30.40
Heal Your Body: The Mental Causes for Physical Illness and the Metaphysical Way to Overcome Them
Hay, Louise
Paperback
$14.24
But You Look Fine: Trapped in the Hell Between Sick and Well and How to Break Free
Kurtz, Amy
Hardcover
$28.50
The Deepest Well: Healing the Long-Term Effects of Childhood Trauma and Adversity
Burke Harris, Nadine
Paperback
$18.04
The Anti-Inflammatory Diet Slow Cooker Cookbook: Prep-And-Go Recipes for Long-Term Healing
Given, Madeline
Paperback
$17.09
5-Minute Chair Yoga for Seniors: Simple Exercises to Improve Mobility and Reclaim Your Confidence
Payge Dolezal, Kierstie
Paperback
$16.14
Glucose Revolution: The Life-Changing Power of Balancing Your Blood Sugar
Inchauspe, Jessie
Hardcover
From $14.99
Longevity Nation: The People, Ideas, and Trends Changing the Second Half of Our Lives
Clinton, Michael
Hardcover
$27.55
The Happiest Baby on the Block: The New Way to Calm Crying and Help Your Newborn Baby Sleep Longer
Karp, Harvey
Paperback
From $11.99
10-Minute Strength Training Exercises for Seniors: Exercises and Routines to Build Muscle, Balance, and Stamina
Deboo, Ed, PT
Paperback
$14.24
Enciende Tu Cerebro: La Clave Para La Felicidad, La Manera de Pensar Y La Salud
Leaf, Dra Caroline
Paperback
$18.04
The Complete Bone and Joint Health Plan: Help Prevent and Treat Osteoporosis and Arthritis
Nitzkorski, Sydney
Wittstein, Jocelyn
Paperback
$23.74
Judas Dentistry: How Dentists Scorn Science, Break the Hippocratic Oath, and Wreck Their Patients' Minds and Bodies
Yoho, (Ret) Robert
Paperback
$23.75
The Girl's Guide to Guts: Everything Your Doc Didn't Tell You (But Your Bestie Would)
Melas, Chloe
Batalion, Judy
Hardcover
$27.55
The Lithium Revolution: Optimizing Mood, Memory, and Lifelong Brain Health With Nutritional Lithium
Greenblatt, James
Paperback
$21.84
Thriving Beyond Fifty (Expanded Edition): 111 Natural Strategies to Restore Your Mobility, Avoid Surgery and Stay Off Pain Pills for Good
Harlow, Will, Msc McSp
Paperback
$23.74
A Never Event: Exposing the Largest Outbreak of Hepatitis C in American Healthcare History
McKnight, Evelyn V.
Bennington, Travis T.
Paperback
$20.34
Chair Yoga for Strength and Balance: Accessible Exercises to Improve Mobility and Relieve Pain
Maitreyi, ML
Paperback
$16.14
The Navy Seal's Survival Guide: The Ultimate Bug In Guide for Crisis Readiness & Self-Reliance
Welch, Alvin K.
Paperback
$19.99
Cocina Antiinflamatoria: Màs de 100 Recetas Para Sanar / Anti-Inflammatory Cooking: More Than 100 Recipes for Healing
Pã(c)Rez, Irelis
Paperback
$23.70
When Women Get Sick: An Empowering Approach for Getting the Support You Need
Bloom, Rebecca
Hardcover
$25.64
Chair Yoga for Seniors: Stretches and Poses That You Can Do Sitting Down at Home
Lehmkuhl, Lynn
Paperback
$17.09
Feeding Tiny Bellies: Over 100 Baby-Led Weaning, Toddler, and Family Recipes: A Cookbook
Payen, Lily
Paperback
$26.60