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Rewiring Pain: The Neuroscience of How the Brain Unlearns Chronic Pain: A Research-Based Guide to Neuroplasticity, Pain Reprocessing, and What the Sci
Paperback
Series: The Pain Science
Medical ReferencePain Management
Publisher: Independently Published
Published: May 10 2026
Pages: 216
Weight: 0.65
Height: 0.46 Width: 6.00 Depth: 9.00
Language: English
Your brain learned chronic pain. The same brain can change it. Here is what the research actually shows.
If you live with chronic pain, you have almost certainly been told one of two things: that the pain is permanent, or that it is the result of damage that cannot be reversed. You have probably read about pain reprocessing therapy, neuroplasticity, and the brain's role in chronic pain, and come away unsure what to believe. Some books promise miracle cures. Some clinicians dismiss the entire field. Neither extreme tells you what the research actually shows.
This book is for the intelligent reader who wants the truth about brain-based pain change, written by a researcher who has followed the literature closely and refuses to overstate or understate what the science says. It is not a self-help programme. It is not a recovery plan. It is a rigorous, honest, and genuinely hopeful explanation of how the brain learns chronic pain, what neuroplasticity means in this specific context, and what the current evidence tells us about the conditions under which a nervous system trained on persistent pain can begin to change.
You will discover what neuroimaging studies show before and after recovery, what the Boulder Back Pain Study actually demonstrated, how graded motor imagery and pain neuroscience education work at a neurological level, and why interoception is central to the mechanism of change rather than a relaxation technique. You will also find a clinically precise chapter on how opioids, benzodiazepines, and other common pain medications interact with the neuroplastic processes that underlie recovery, equipping you with the research you need to have a more informed conversation with your prescribing clinician.
Inside this book you will learn:
- How the brain learns to produce chronic pain through prediction, fear, and protective behaviour, and why understanding the mechanism is the first step toward changing it
- What neuroplasticity actually means in the context of pain, stripped of wellness clichés and grounded in current neuroscience
- What the leading clinical trials in pain reprocessing therapy have shown, including effect sizes, populations, limitations, and what remains unresolved
- Why interoception, the brain's capacity to read internal body signals, is the specific neurological mechanism through which somatic tracking and pain reprocessing work
- How graded exposure reduces the threat value of movement through prediction error and fear extinction, not simply by pushing through pain
- How benzodiazepines may interfere with fear extinction learning, what the opioid-induced hyperalgesia research reveals, and what the evidence shows about SNRIs and neuroplasticity
- What predicts who responds to brain-based approaches and who does not, and what to do when progress stalls
- What the long-term follow-up data shows about maintaining recovery, navigating setbacks, and the non-linear path most patients actually walk
This is the book to read before, during, or alongside whatever clinical treatment you are pursuing. It will not promise that your pain is reversible. It will give you a clear, evidence-grounded understanding of what is possible, what is uncertain, and why the brain that learned to hurt holds the capacity to change.
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