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Avaliação da atividade analgésica
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ISBN10: 6630130693
ISBN13: 9786630130690
Publisher: Edicoes Nosso Conhecimento
Published: Jun 10 2026
Pages: 52
Weight: 0.18
Height: 0.12 Width: 6.00 Depth: 9.00
Language: Portuguese
ISBN13: 9786630130690
Publisher: Edicoes Nosso Conhecimento
Published: Jun 10 2026
Pages: 52
Weight: 0.18
Height: 0.12 Width: 6.00 Depth: 9.00
Language: Portuguese
O presente estudo consiste em avaliar a atividade analgésica do extrato SAC-Pa utilizando estÃmulos algogênicos (ácido acético a 0,6% por via intraperitoneal, formaldeÃdo a 1% por via intraplantar, placa aquecedora a 56 C, pinçamento da cauda) para provocar dor em ratos. A administração oral do extrato SAC-Pa em doses de 250 e 500 mg/kg demonstra atividade analgésica periférica, evidenciada pelo teste do ácido acético e pelo teste do formaldeÃdo. O extrato diminui o número de contorções abdominais provocadas pelo ácido acético em 30,35% e 77,25%. Reduz também o tempo de lambidelas e mordidas na pata que recebeu formaldeÃdo durante a 2.a fase em 71,22% e 82,99%. A administração do extrato SAC-Pa (250 e 500 mg/kg) por via oral não demonstra atividade analgésica central. O extrato SAC-Pa não aumenta nem o tempo de reação dos ratos na placa aquecedora nem o tempo de reação ao beliscão na cauda. Estes resultados mostram que o extrato SAC-Pa possui apenas uma atividade analgésica periférica, que poderia ser atribuÃda aos alcalóides que contém.
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