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Bewertung der schmerzstillenden Wirkung
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ISBN10: 6630117891
ISBN13: 9786630117899
Publisher: Verlag Unser Wissen
Published: Jun 10 2026
Pages: 56
Weight: 0.19
Height: 0.13 Width: 6.00 Depth: 9.00
Language: German
ISBN13: 9786630117899
Publisher: Verlag Unser Wissen
Published: Jun 10 2026
Pages: 56
Weight: 0.19
Height: 0.13 Width: 6.00 Depth: 9.00
Language: German
Die vorliegende Studie dient der Bewertung der schmerzstillenden Wirkung des SAC-Pa-Extrakts unter Verwendung algogener Reize (0,6 %ige Essigsäure intraperitoneal, 1 %iges Formaldehyd intraplantar, Heizplatte bei 56 C, Schwanzkneifen), um bei Mäusen Schmerzen auszulösen. Die orale Verabreichung des SAC-Pa-Extrakts in Dosen von 250 und 500 mg/kg zeigt eine periphere schmerzstillende Wirkung, die durch den Essigsäure- und den Formaldehyd-Test nachgewiesen wurde. Der Extrakt verringert die Anzahl der durch Essigsäure hervorgerufenen Bauchkrämpfe um 30,35 % bzw. 77,25 %. Er reduziert zudem die Zeit des Leckens und Bei ens an der mit Formaldehyd behandelten Pfote während der zweiten Phase um 71,22 % bzw. 82,99 %. Die orale Verabreichung des SAC-Pa-Extrakts (250 und 500 mg/kg) zeigt keine zentral analgetische Wirkung. Der SAC-Pa-Extrakt verlängert weder die Reaktionszeit der Mäuse auf der Heizplatte noch die beim Kneifen ihres Schwanzes. Diese Ergebnisse zeigen, dass der SAC-Pa-Extrakt ausschlie lich eine periphere schmerzstillende Wirkung besitzt, die auf die darin enthaltenen Alkaloide zurückgeführt werden könnte.
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