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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Evaluation of the analgesic activity

Evaluation of the analgesic activity

Randriamahefa, Vanessa

Paperback

Biology

ISBN10: 6630120450
ISBN13: 9786630120455
Publisher: Our Knowledge Publishing
Published: Jun 10 2026
Pages: 52
Weight: 0.18
Height: 0.12 Width: 6.00 Depth: 9.00
Language: English
This study aims to evaluate the analgesic activity of the SAC-Pa extract using algogenic stimuli (0.6% acetic acid administered intraperitoneally, 1% formaldehyde administered intraplantarly, a 56 C heating plate, and tail pinch) to induce pain in mice. Oral administration of the SAC-Pa extract at doses of 250 and 500 mg/kg demonstrates peripheral analgesic activity, as evidenced by the acetic acid test and the formaldehyde test. The extract reduced the number of abdominal writhing episodes induced by acetic acid by 30.35% and 77.25%. It also reduced the time spent licking and biting the paw treated with formaldehyde during the second phase by 71.22% and 82.99%. Oral administration of the SAC-Pa extract (250 and 500 mg/kg) did not demonstrate central analgesic activity. The SAC-Pa extract did not increase the reaction time of mice on the hot plate or when their tails were pinched. These results show that the SAC-Pa extract possesses only peripheral analgesic activity, which could be attributed to the alkaloids it contains.

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