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Ocena dzialania przeciwbólowego
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ISBN10: 6630115333
ISBN13: 9786630115338
Publisher: Wydawnictwo Nasza Wiedza
Published: Jun 10 2026
Pages: 52
Weight: 0.18
Height: 0.12 Width: 6.00 Depth: 9.00
Language: Polish
ISBN13: 9786630115338
Publisher: Wydawnictwo Nasza Wiedza
Published: Jun 10 2026
Pages: 52
Weight: 0.18
Height: 0.12 Width: 6.00 Depth: 9.00
Language: Polish
Niniejsze badanie polega na ocenie dzialania przeciwbólowego ekstraktu SAC-Pa przy użyciu bodźców bólowych (0,6% kwas octowy podawany dootrzewnowo, 1% formaldehyd podawany śródskórnie, plyta grzewcza o temperaturze 56 C, ściskanie ogona) w celu wywolania bólu u myszy. Podanie ekstraktu SAC-Pa drogą doustną w dawkach 250 i 500 mg/kg wykazuje dzialanie przeciwbólowe w ukladzie obwodowym, co potwierdzono w teście z kwasem octowym i teście z formaldehydem. Ekstrakt zmniejsza liczbę skurczów brzucha wywolanych kwasem octowym o 30,35% i 77,25%. Skraca również czas lizania i gryzienia lapki, na którą nalożono formaldehyd, w drugiej fazie o 71,22% i 82,99%. Podanie doustne wyciągu SAC-Pa (250 i 500 mg/kg) nie wykazuje dzialania przeciwbólowego o dzialaniu ośrodkowym. Wyciąg SAC-Pa nie wydluża czasu reakcji myszy na plytce grzewczej ani czasu reakcji na uszczypnięcie ogona. Wyniki te wskazują, że wyciąg SAC-Pa wykazuje wylącznie obwodowe dzialanie przeciwbólowe, które można przypisac zawartym w nim alkaloidom.
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