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Valutazione dell'attività analgesica
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ISBN10: 6630128133
ISBN13: 9786630128130
Publisher: Edizioni Sapienza
Published: Jun 10 2026
Pages: 52
Weight: 0.18
Height: 0.12 Width: 6.00 Depth: 9.00
Language: Italian
ISBN13: 9786630128130
Publisher: Edizioni Sapienza
Published: Jun 10 2026
Pages: 52
Weight: 0.18
Height: 0.12 Width: 6.00 Depth: 9.00
Language: Italian
Il presente studio consiste nel valutare l'attività analgesica dell'estratto SAC-Pa utilizzando stimoli algogenici (acido acetico allo 0,6% per via intraperitoneale, formaldeide all'1% per via intraplantar, piastra riscaldante a 56 C, pizzicamento della coda) per provocare dolore nei topi. La somministrazione orale dell'estratto SAC-Pa a dosi di 250 e 500 mg/kg mostra un'attività analgesica periferica evidenziata dal test con acido acetico e dal test con formaldeide. L'estratto riduce il numero di contorsioni addominali provocate dall'acido acetico del 30,35% e del 77,25%. Riduce inoltre il tempo di leccamento e di mordicchiamento della zampa trattata con formaldeide durante la seconda fase del 71,22% e dell'82,99%. La somministrazione dell'estratto SAC-Pa (250 e 500 mg/kg) per via orale non mostra attività analgesica centrale. L'estratto SAC-Pa non aumenta né il tempo di reazione dei topi sulla piastra riscaldante né quello alla pinzatura della coda. Questi risultati dimostrano che l'estratto SAC-Pa possiede esclusivamente un'attività analgesica periferica che potrebbe essere attribuita agli alcaloidi in esso contenuti.
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