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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Choroid Plexus Pharmacology

Choroid Plexus Pharmacology

Baehr, Carsten H.

Paperback

ManagementMedical Reference

ISBN10: 3639057406
ISBN13: 9783639057409
Publisher: Blues Kids Of Amer
Published: Jul 10 2008
Pages: 148
Weight: 0.46
Height: 0.32 Width: 6.00 Depth: 9.00
Language: English
The choroid plexus (CP) epithelium forms the blood-cerebrospinal fluid (CSF) barrier and, along with the blood-brain barrier, maintains the fluid environment of the brain. The CP not only secretes CSF, but also transports potentially toxic xenobiotics and waste products of neural metabolism to the blood for eventual clearance in kidney and liver. However, studying CP is difficult, due to complex morphology, ana-tomical location and small size of the tissue and little is known about the molecular mechanisms, functional complexity and hormonal regu-lation of organic anion secretion. To further elucidate the underlying mechanisms of organic anion transport across CP epithelium, a pri-mary porcine CP cell culture model was established and characterized. Organic anion transport was studied in a mammalian (rat), a comparative elasmobranch and in an in vitro porcine cell culture mo-del, using model compound fluorescein-methotrexate. Organic anion transport was shown to be a specific and concentrative, Na-ion dependent and metabolism-dependent two-step process. Finally, for the first time, the studies demonstrated that organic anion transport is regulated by protein kinase (PK) C and PKA.

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