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Advances in Fertility Control and the Treatment of Sterility: The Proceedings of a Special Symposium Held at the Xith World Congress on Fertility and

Advances in Fertility Control and the Treatment of Sterility: The Proceedings of a Special Symposium Held at the Xith World Congress on Fertility and

Paperback

Medical ReferenceWomen's Health

ISBN10: 9401159327
ISBN13: 9789401159326
Publisher: Springer Nature
Published: Jan 28 2012
Pages: 117
Weight: 0.39
Height: 0.25 Width: 6.14 Depth: 9.21
Language: English
Since human prolactin was isolated and characterized 13 years ago, the study of the control of prolactin secretion has been intensive. Hyperprolactinaemia is the most commonly identifiable hypothal- amic pituitary disorder1,2. The dominant inhibitory nature of hypo- thalamic control of prolactin secretion may be the reason that hyperprolactinaemia is such a common condition. During the PClst decade two separate therapeutic approaches to the management of hyperprolactinaemia have been introduced: transsphenoidal selec- tive pituitary microsurgery and medical therapy to suppress prolactin secretion with orally active long-acting dopamine agonist drugs. Small prolactin-secreting tumours are treated extremely satisfactorily both with medical and with surgical therapy, both in terms of lower- ing serum prolactin levels to normal and in restoring gonadal func- tion. However, for the larger tumours, either where the tumour is invasive or the pretreatment serum prolactin level is greater than 1 250ngml- the results of surgery are poor in terms of restoring to normal circulating prolactin levels and gonadal functionJ-s. We now discuss the medical management of hyperprolactinaemia, potential problems during pregnancy and the management of large prolactin- secreting pituitary tumours.

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