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The Construction of Analogy-Based Research Programs: The Lock-And-Key Analogy in 20th Century Biochemistry

The Construction of Analogy-Based Research Programs: The Lock-And-Key Analogy in 20th Century Biochemistry

Paperback

Series: Science Studies

PhilosophySports GeneralHistory & Philosophy of Science

Currently unavailable to order

ISBN10: 3837644421
ISBN13: 9783837644425
Publisher: Transcript Publishing
Published: Sep 17 2019
Pages: 230
Weight: 0.80
Height: 0.70 Width: 5.80 Depth: 8.90
Language: English
When the German chemist Emil Fischer presented his key-lock hypothesis in 1899, his analogy to describe the molecular relationship between enzymes and substrates quickly gained vast influence and provided future generations of scientists with a tool to investigate the relation between chemical structure and biological specificity. Rebecca Mertens explains the appeal of the lock-and-key analogy by its role in model building and in the construction of long-term, cross-generational research programs. She argues that a crucial feature of these research programs, namely ascertaining the continuity of core ideas and concepts, is provided by a certain way of analogy-based modeling.

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