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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Substituted Methanimine Derivatives: Neurodegenerative Disease

Substituted Methanimine Derivatives: Neurodegenerative Disease

Swaminathan, Gomathi
Rajagopal, Kalirajan
M, Navinkumar

Paperback

Medical Reference

ISBN10: 6209575706
ISBN13: 9786209575709
Publisher: LAP Lambert Academic Publishing
Published: Jan 23 2026
Pages: 52
Weight: 0.18
Height: 0.12 Width: 6.00 Depth: 9.00
Language: English
Parkinson's disease (PD) is a progressive neurodegenerative disorder marked by the degeneration of dopaminergic neurons in the striatum and the presence of Lewy bodies composed mainly of α-synuclein. Sirtuin 2 (SIRT2), a class III histone deacetylase, is known to influence key cellular functions such as genome integrity, mitochondrial regulation, autophagy, and apoptosis. Increased SIRT2 expression in aging and PD models highlights its relevance as a potential therapeutic target. In this study, a set of Benzoxazole-based methanimine derivatives, (E)-1-Phenyl-N-(2-Phenyl)-1,3-benzoxazol-6-yl) methanimine analogues (NOV 1-3), were designed and evaluated for their inhibitory potential against SIRT2. The target protein (PDB ID: 5YQL) was obtained from the RCSB PDB database, refined through loop modelling, and energy-minimized before molecular docking analysis. Docking studies showed that NOV 1-3 exhibited strong binding affinities and key interactions within the SIRT2 active site, suggesting effective inhibition. The synthesized compounds were structurally confirmed using IR, NMR, and mass spectroscopy.

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