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Reparação de incompatibilidades de DNA e sistema de pontos de controlo durante a meiose
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ISBN10: 6209979793
ISBN13: 9786209979798
Publisher: Edicoes Nosso Conhecimento
Published: May 13 2026
Pages: 60
Weight: 0.21
Height: 0.14 Width: 6.00 Depth: 9.00
Language: Portuguese
ISBN13: 9786209979798
Publisher: Edicoes Nosso Conhecimento
Published: May 13 2026
Pages: 60
Weight: 0.21
Height: 0.14 Width: 6.00 Depth: 9.00
Language: Portuguese
A T. thermophila é um bom organismo modelo para a investigação da reparação de incompatibilidades de DNA (MMR). O seu corpo unicelular de grandes dimensões facilita a observação das alterações nos cromossomas. A sua conjugação (acasalamento) é induzÃvel, o que constitui uma vantagem para o estudo das funções das proteÃnas durante a meiose. A MMR aumenta a fidelidade da replicação do DNA. Os sistemas de pontos de controlo mantêm a integridade genómica no ciclo celular. Se se acumular um determinado nÃvel de danos no ADN, resultante do processo de replicação ou de agentes que danificam o ADN, o ciclo celular será interrompido para permitir a verificação e reparação dos danos. Existem pontos de controlo mitóticos e pontos de controlo meióticos. No entanto, o mecanismo dos sistemas de pontos de controlo meióticos ainda é incerto. Neste livro, a relação entre o ponto de controlo meiótico e a MMR do ADN foi estudada em T. thermophila, o que é interessante para compreender o sistema de pontos de controlo meióticos em eucariotas.
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