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DNA-Mismatch-Reparatur und Checkpoint-System während der Meiose
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ISBN10: 6209969550
ISBN13: 9786209969553
Publisher: Verlag Unser Wissen
Published: May 13 2026
Pages: 64
Weight: 0.22
Height: 0.15 Width: 6.00 Depth: 9.00
Language: German
ISBN13: 9786209969553
Publisher: Verlag Unser Wissen
Published: May 13 2026
Pages: 64
Weight: 0.22
Height: 0.15 Width: 6.00 Depth: 9.00
Language: German
T. thermophila ist ein geeigneter Modellorganismus für die Erforschung der DNA-Mismatch-Reparatur (MMR). Dank ihres gro en einzelligen Körpers lassen sich Veränderungen an den Chromosomen leicht feststellen. Ihre Konjugation (Paarung) ist induzierbar, was für die Untersuchung von Proteinfunktionen während der Meiose von Vorteil ist. Die MMR erhöht die Genauigkeit der DNA-Replikation. Checkpoint-Systeme gewährleisten die genomische Integrität innerhalb des Zellzyklus. Wenn sich durch den Replikationsprozess oder durch DNA-schädigende Substanzen ein bestimmtes Ma an DNA-Schäden angesammelt hat, wird der Zellzyklus angehalten, um die Schäden zu überprüfen und zu reparieren. Es gibt mitotische Checkpoints und meiotische Checkpoints. Der Mechanismus der meiotischen Checkpoint-Systeme ist jedoch noch unklar. In diesem Buch wurde die Beziehung zwischen dem meiotischen Checkpoint und der DNA-MMR bei T. thermophila untersucht, was für das Verständnis des meiotischen Checkpoint-Systems in Eukaryoten von Interesse ist.
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