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Riparazione dei mismatch del DNA e sistema di checkpoint durante la meiosi
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ISBN10: 6209977235
ISBN13: 9786209977237
Publisher: Edizioni Sapienza
Published: May 13 2026
Pages: 64
Weight: 0.22
Height: 0.15 Width: 6.00 Depth: 9.00
Language: Italian
ISBN13: 9786209977237
Publisher: Edizioni Sapienza
Published: May 13 2026
Pages: 64
Weight: 0.22
Height: 0.15 Width: 6.00 Depth: 9.00
Language: Italian
La T. thermophila è un ottimo organismo modello per la ricerca sulla riparazione dei mismatch del DNA (MMR). Il suo grande corpo unicellulare facilita l'osservazione dei cambiamenti a livello cromosomico. La sua coniugazione (accoppiamento) è inducibile, il che rappresenta un vantaggio per lo studio delle funzioni proteiche durante la meiosi. L'MMR aumenta la fedeltà della replicazione del DNA. I sistemi di checkpoint mantengono l'integrità genomica all'interno del ciclo cellulare. Se si è accumulato un certo livello di danno al DNA a causa del processo di replicazione o di agenti che danneggiano il DNA, il ciclo cellulare viene arrestato per consentire il controllo e la riparazione del danno. Esistono checkpoint mitotici e checkpoint meiotici. Tuttavia, il meccanismo dei sistemi di checkpoint meiotici è ancora incerto. In questo libro, la relazione tra il checkpoint meiotico e la riparazione dei mismatch del DNA (MMR) è stata studiata in T. thermophila, il che è interessante per comprendere il sistema di checkpoint meiotico negli eucarioti.
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