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Receptor EphA7
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ISBN10: 6630021444
ISBN13: 9786630021448
Publisher: Edicoes Nosso Conhecimento
Published: May 24 2026
Pages: 52
Weight: 0.18
Height: 0.12 Width: 6.00 Depth: 9.00
Language: Portuguese
ISBN13: 9786630021448
Publisher: Edicoes Nosso Conhecimento
Published: May 24 2026
Pages: 52
Weight: 0.18
Height: 0.12 Width: 6.00 Depth: 9.00
Language: Portuguese
O EphA7 é um membro da famÃlia dos recetores de tirosina quinase Eph, que regulam a aderência e a motilidade celular. O EphA7 é altamente conservado nos vertebrados e amplamente expresso durante a embriogênese, em particular durante o desenvolvimento do SNC. No cérebro adulto, o EphA7 é transcrito principalmente no hipocampo, com baixos nÃveis de expressão noutras áreas. Cartografámos a sua distribuição no cérebro de ratos e ratinhos adultos, através de hibridização in situ e imuno-histoquÃmica em microscopia fotónica e eletrónica. Ambos os métodos revelam uma distribuição de marcação muito consistente. O sinal mais forte foi observado no hipocampo, com nÃveis menos elevados na habénula, no estriado, na amÃgdala, nos córtex cingular, piriforme e entorrinal, bem como no cerebelo. Ao nÃvel ultraestrutural, no hipocampo, a imunorreatividade de EphA7 foi localizada no citoplasma das células granulares (giro dentado) e piramidais (CA1 e CA3). A localização preferencial de EphA7 nas espinhas dendrÃticas e nos prolongamentos astrocitários perissinápticos é consistente com o seu papel na plasticidade sináptica.
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