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Recettore EphA7
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ISBN10: 6630016327
ISBN13: 9786630016321
Publisher: Edizioni Sapienza
Published: May 24 2026
Pages: 52
Weight: 0.18
Height: 0.12 Width: 6.00 Depth: 9.00
Language: Italian
ISBN13: 9786630016321
Publisher: Edizioni Sapienza
Published: May 24 2026
Pages: 52
Weight: 0.18
Height: 0.12 Width: 6.00 Depth: 9.00
Language: Italian
EphA7 appartiene alla famiglia dei recettori tirosin-chinasi Eph, che regolano l'adesione e la motilità cellulare. EphA7 è altamente conservato nei vertebrati ed è ampiamente espresso durante l'embriogenesi, in particolare durante lo sviluppo del sistema nervoso centrale. Nel cervello adulto, EphA7 è trascritto principalmente nell'ippocampo, con bassi livelli di espressione altrove. Abbiamo mappato la sua distribuzione nel cervello di ratti e topi adulti, mediante ibridazione in situ e immunoistochimica al microscopio ottico ed elettronico. Entrambi i metodi mostrano una distribuzione del marcatore molto coerente. Il segnale più forte è stato osservato nell'ippocampo, con livelli meno elevati nell'abenula, nello striato, nell'amigdala, nelle cortecce cingolata, piriforme ed entorinale, nonché nel cervelletto. A livello ultrastrutturale, nell'ippocampo, l'immunoreattività di EphA7 è stata localizzata nel citoplasma delle cellule granulari (giro dentato) e piramidali (CA1 e CA3). La localizzazione preferenziale di EphA7 nelle spine dendritiche e nelle propaggini astrocitarie perisynaptiche è coerente con il suo ruolo nella plasticità sinaptica.
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