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EphA7-Rezeptor
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ISBN10: 6630008642
ISBN13: 9786630008647
Publisher: Verlag Unser Wissen
Published: May 24 2026
Pages: 56
Weight: 0.19
Height: 0.13 Width: 6.00 Depth: 9.00
Language: German
ISBN13: 9786630008647
Publisher: Verlag Unser Wissen
Published: May 24 2026
Pages: 56
Weight: 0.19
Height: 0.13 Width: 6.00 Depth: 9.00
Language: German
EphA7 gehört zur Familie der Eph-Tyrosinkinase-Rezeptoren, die die Zelladhäsion und -motilität regulieren. EphA7 ist bei Wirbeltieren hochkonserviert und wird während der Embryogenese, insbesondere während der Entwicklung des Zentralnervensystems, in gro em Umfang exprimiert. Im adulten Gehirn wird EphA7 hauptsächlich im Hippocampus transkribiert, während an anderen Stellen nur geringe Expressionsniveaus zu verzeichnen sind. Wir haben seine Verteilung im Gehirn erwachsener Ratten und Mäuse mittels In-situ-Hybridisierung sowie immunhistochemischer Untersuchungen unter dem Licht- und Elektronenmikroskop kartiert. Beide Methoden zeigen eine sehr konsistente Markierungsverteilung. Das stärkste Signal wurde im Hippocampus beobachtet, mit geringeren Werten in der Habena, dem Striatum, der Amygdala, dem cingulären, piriformen und entorhinalen Kortex sowie im Kleinhirn. Auf ultrastruktureller Ebene wurde im Hippocampus die Immunreaktivität von EphA7 im Zytoplasma der Granularzellen (Gyrus dentatus) und Pyramidenzellen (CA1 und CA3) lokalisiert. Die bevorzugte Lokalisierung von EphA7 in dendritischen Dornen und perisynaptischen Astrozytenfortsätzen steht im Einklang mit seiner Rolle bei der synaptischen Plastizität.
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