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Genotoxicidade e carcinogenicidade dos alcalóides da Rhazya stricta
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ISBN10: 6209949959
ISBN13: 9786209949951
Publisher: Edicoes Nosso Conhecimento
Published: Apr 24 2026
Pages: 120
Weight: 0.38
Height: 0.28 Width: 6.00 Depth: 9.00
Language: Portuguese
ISBN13: 9786209949951
Publisher: Edicoes Nosso Conhecimento
Published: Apr 24 2026
Pages: 120
Weight: 0.38
Height: 0.28 Width: 6.00 Depth: 9.00
Language: Portuguese
Nos paÃses asiáticos, a R. stricta tem sido tradicionalmente utilizada como remédio à base de plantas para o tratamento de várias doenças em animais e humanos. Estudos recentes centraram-se na identificação e caracterização de ingredientes farmacêuticos ativos especÃficos da R. stricta e de outras plantas medicinais da Arábia Saudita. A sÃndrome metabólica (MetS; também chamada de SÃndrome X ou sÃndrome de resistência à insulina), uma combinação de distúrbios metabólicos, aumenta a vulnerabilidade ao desenvolvimento de doenças cardiovasculares, obesidade e diabetes. O objetivo deste estudo foi avaliar o efeito de vários extratos alcalóides das folhas de R. stricta (um extrato aquoso total, uma fração contendo alcalóides e uma fração sem alcalóides deste extrato) sobre parâmetros bioquÃmicos associados à sÃndrome metabólica em animais. A genotoxicidade e a carcinogenicidade da fração alcalóide isolada do extrato aquoso de Rhazya stricta foram avaliadas molecularmente por RAPD e Comet e citogeneticamente pelo teste do micronúcleo. Além disso, as frações alcalóides devem ser identificadas e testadas separadamente para determinar o componente dos alcalóides presentes no extrato aquoso que é responsável pelo seu efeito mutagénico.
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