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Genotoxizität und Karzinogenität von Alkaloiden aus Rhazya stricta
Paperback
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ISBN10: 6209939716
ISBN13: 9786209939716
Publisher: Verlag Unser Wissen
Published: Apr 24 2026
Pages: 128
Weight: 0.40
Height: 0.30 Width: 6.00 Depth: 9.00
Language: German
ISBN13: 9786209939716
Publisher: Verlag Unser Wissen
Published: Apr 24 2026
Pages: 128
Weight: 0.40
Height: 0.30 Width: 6.00 Depth: 9.00
Language: German
In asiatischen Ländern wird R. stricta traditionell als pflanzliches Heilmittel zur Behandlung verschiedener Tier- und Humanerkrankungen eingesetzt. Jüngste Studien konzentrierten sich auf die Identifizierung und Charakterisierung spezifischer pharmazeutischer Wirkstoffe aus R. stricta und anderen saudiarabischen Heilpflanzen. Das metabolische Syndrom (MetS; auch als Syndrom X oder Insulinresistenzsyndrom bezeichnet), eine Kombination von Stoffwechselstörungen, erhöht die Anfälligkeit für die Entwicklung von Herz-Kreislauf-Erkrankungen, Adipositas und Diabetes. Ziel dieser Studie war es, die Wirkung verschiedener Alkaloidextrakte aus R. stricta-Blättern (ein vollständiger wässriger Extrakt sowie eine alkaloidhaltige und eine nicht-alkaloidhaltige Fraktion dieses Extrakts) auf biochemische Parameter im Zusammenhang mit dem metabolischen Syndrom bei Tieren zu untersuchen. Die Genotoxizität und Karzinogenität der aus dem wässrigen Extrakt von Rhazya stricta isolierten Alkaloidfraktion wurde molekular mittels RAPD- und Comet-Test sowie zytogenetisch mittels Mikronukleustest untersucht. Darüber hinaus sollten die Alkaloidfraktionen identifiziert und separat getestet werden, um die im wässrigen Extrakt enthaltenen Alkaloidkomponenten zu bestimmen, die für dessen mutagene Wirkung verantwortlich sind.
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