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Genotossicità e cancerogenicità degli alcaloidi della Rhazya stricta
Paperback
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ISBN10: 6209947395
ISBN13: 9786209947391
Publisher: Edizioni Sapienza
Published: Apr 24 2026
Pages: 120
Weight: 0.38
Height: 0.28 Width: 6.00 Depth: 9.00
Language: Italian
ISBN13: 9786209947391
Publisher: Edizioni Sapienza
Published: Apr 24 2026
Pages: 120
Weight: 0.38
Height: 0.28 Width: 6.00 Depth: 9.00
Language: Italian
Nei paesi asiatici, la R. stricta è stata tradizionalmente utilizzata come rimedio erboristico per il trattamento di varie malattie animali e umane. Recenti studi si sono concentrati sull'identificazione e la caratterizzazione di specifici principi attivi farmaceutici della R. stricta e di altre piante medicinali dell'Arabia Saudita. La sindrome metabolica (MetS; chiamata anche Sindrome X o sindrome da insulino-resistenza), una combinazione di disturbi metabolici, aumenta la vulnerabilità allo sviluppo di malattie cardiovascolari, obesità e diabete. Lo scopo di questo studio era valutare l'effetto di vari estratti alcaloidi delle foglie di R. stricta (un estratto acquoso totale, una frazione contenente alcaloidi e una frazione priva di alcaloidi di questo estratto) sui parametri biochimici associati alla sindrome metabolica negli animali. La genotossicità e la cancerogenicità della frazione alcaloide isolata dall'estratto acquoso di Rhazya stricta sono state valutate a livello molecolare mediante RAPD e Comet e a livello citogenetico mediante il test del micronucleo. Inoltre, le frazioni alcaloidi devono essere identificate e testate separatamente per determinare quali componenti alcaloidi presenti nell'estratto acquoso siano responsabili del suo effetto mutageno.
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