Open Daily: 10am - 10pm | Alley door pickup 10am - 7pm 3038 Hennepin Ave Minneapolis, MN
612-822-4611

  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Cystic Fibrosis

Cystic Fibrosis

Gourari-Bouzouina, Karima
Boucherit-Otmani, Zahia

Paperback

Biology

ISBN10: 6209166717
ISBN13: 9786209166716
Publisher: LAP Lambert Academic Publishing
Published: Oct 31 2025
Pages: 100
Weight: 0.32
Height: 0.24 Width: 6.00 Depth: 9.00
Language: English
Cystic fibrosis (CF) is a lethal genetic disorder mainly affecting Caucasians, caused by mutations in the CFTR gene encoding a chloride ion channel. The most common ∆F508 mutation alters CFTR folding and prevents its expression on epithelial cell surfaces, disrupting ion and water transport and leading to thick mucus, a hallmark of CF lung disease. Treatments have advanced, with antibiotics managing chronic infections and CFTR modulators (ivacaftor, tezacaftor, elexacaftor) improving protein function. Yet, many patients with rare mutations or drug resistance remain untreated. Emerging therapies now focus on gene therapy to correct or replace the defective CFTR gene and on cell therapy to regenerate functional epithelium from corrected stem cells. Combining these strategies offers a promising path toward personalized, long-term correction of the molecular cause of CF.

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