Open Daily: 10am - 10pm | Alley door pickup 10am - 7pm 3038 Hennepin Ave Minneapolis, MN
612-822-4611

  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Structural Insights Into Coronavirus Binding to Host Amino Peptidase

Structural Insights Into Coronavirus Binding to Host Amino Peptidase

Soni, Veena

Paperback

Business General

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ISBN10: 6202530405
ISBN13: 9786202530408
Publisher: Lap Lambert Academic Pub
Published: May 30 2020
Pages: 140
Weight: 0.47
Height: 0.33 Width: 6.00 Depth: 9.00
Language: English
Coronaviruses (CoV) are large enveloped RNA viruses of animals and humans associated mostly with enteric and respiratory diseases. These viruses were earlier considered more of a veterinary interest and were associated to humans with mild flu. The last decade brought outbreaks with high mortality rates caused by CoV transmission from animals to man. This remarkable cross-species transmission potential is related to CoV adaptation to a variety of cell surface molecules for entry into host cells. The CoV particles bear exposed spike (S)proteins in their envelope that attach to specific cell entry receptors, which determines CoV host cell range and tropism. CoV can recognize diverse entry receptors, but they preferentially use membrane bound ectoenzymes. A subset of CoV recognizes the cell surface aminopeptidase N (APN), a membrane-bound metalloprotease. APN (CD13) is a moonlighting ectoenzyme linked to multiple functions such asangiogenesis, cell adhesion and tumorogenesis. It cleaves neutral amino acid side chains fromthe N-terminus of oligopeptides. It is distributed in wide variety of tissues and its expressionis dysregulated in tumors.

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