Open Daily: 10am - 10pm | Alley door pickup 10am - 7pm 3038 Hennepin Ave Minneapolis, MN
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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Role of glutamatergic receptors in brain development

Role of glutamatergic receptors in brain development

Oliveira Sousa Corrêa, Vivian

Paperback

Business General

ISBN10: 6208478499
ISBN13: 9786208478490
Publisher: Our Knowledge Publishing
Published: Aug 29 2025
Pages: 100
Weight: 0.32
Height: 0.24 Width: 6.00 Depth: 9.00
Language: English
Neuroglial interactions play a key role in the development of the nervous system. This study investigated the role of synaptic transmitters (glutamate and D-serine) and a trophic factor, transforming growth factor-β1 (TGF-β1), as mediators of these interactions during the differentiation of radial glial cells (neural progenitors) and astrocytes. Our data suggest a possible role for NMDA-type glutamatergic receptors in GR specialization during neuronal migration in the cerebral cortex. We also analyzed the role of glutamate in astrocytic maturation through TGF-β1 pathways. The activation of metabotropic glutamate receptors 2/3 by neurons induces the secretion of TGF-β1, leading to the activation of the GFAP gene and astrocyte maturation. Both the production of TGF-β1 and the activation of the GFAP gene by this factor involve the MAPK/PI3K pathways. Our work shows that glutamatergic receptors are involved in events of cerebral cortex development such as GR specification and astrocyte maturation.

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