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Neurofarmacologia da Coccinia grandis - Neuropatia diabética
Paperback
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ISBN10: 6209834302
ISBN13: 9786209834301
Publisher: Edicoes Nosso Conhecimento
Published: Mar 27 2026
Pages: 260
Weight: 0.78
Height: 0.59 Width: 6.00 Depth: 9.00
Language: Portuguese
ISBN13: 9786209834301
Publisher: Edicoes Nosso Conhecimento
Published: Mar 27 2026
Pages: 260
Weight: 0.78
Height: 0.59 Width: 6.00 Depth: 9.00
Language: Portuguese
A dor neuropática diabética é uma condição extremamente debilitante e geralmente difÃcil de tratar. O extrato metanólico de Coccinia grandis foi testado quanto à sua ação analgésica e anti-inflamatória num modelo de rato com neuropatia diabética induzida por STZ. A atividade inflamatória aguda foi estudada pelo teste de dor de Randal. Foram determinados no nervo ciático e no cérebro os mediadores nociceptivos, a coordenação neuromuscular, fatores eletrofisiológicos e inflamatórios, como a ciclo-oxigenase e a PG peroxidase, que contribuem para a dor neuropática. A atividade analgésica foi estudada em ratos utilizando os testes da placa quente e de retirada da cauda (tail-flick). Foram determinadas alterações neuroquÃmicas, como glicose, frutose, sorbitol e glutationa reduzida no nervo ciático e no cérebro. Enzimas como a hexoquinase, a aldose redutase, a sorbitol desidrogenase e a glicose-6-fosfato desidrogenase também foram determinadas após 3 semanas. Foi também estudada a alteração histopatológica do nervo ciático e do cérebro. Foi estudada a patologia de todos os órgãos vitais, como rim, fÃgado e intestino. Em conclusão, o extrato da folha de Coccinia grandis possui atividades anti-inflamatórias e analgésicas, efeito antidiabético e não tóxico.
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