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Neuropharmacologie de Coccinia grandis - Neuropathie diabétique
Paperback
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ISBN10: 6209826628
ISBN13: 9786209826627
Publisher: Editions Notre Savoir
Published: Mar 27 2026
Pages: 268
Weight: 0.80
Height: 0.61 Width: 6.00 Depth: 9.00
Language: French
ISBN13: 9786209826627
Publisher: Editions Notre Savoir
Published: Mar 27 2026
Pages: 268
Weight: 0.80
Height: 0.61 Width: 6.00 Depth: 9.00
Language: French
La douleur neuropathique diabétique est une affection extrêmement débilitante et généralement difficile à traiter. L'extrait méthanolique de Coccinia grandis a été testé pour son action analgésique et anti-inflammatoire sur un modèle de rat neuropathique diabétique induit par la STZ. L'activité inflammatoire aiguë a été étudiée par le test de douleur de Randal. La coordination nociceptive, neuromusculaire, les médiateurs électrophysiologiques et inflammatoires tels que la cyclooxygénase et la PG peroxydase qui contribuent à la douleur neuropathique ont été déterminés dans le nerf sciatique et le cerveau. L'activité analgésique a été étudiée chez le rat à l'aide des tests de la plaque chauffante et du retrait de la queue (tail-flick). Des altérations neurochimiques telles que le glucose, le fructose, le sorbitol et le glutathion réduit ont été déterminées dans le nerf sciatique et le cerveau. Des enzymes telles que l'hexokinase, l'aldose réductase, la sorbitol déshydrogénase et la glucose-6-phosphate déshydrogénase ont également été déterminées après 3 semaines. Une altération histopathologique du nerf sciatique et du cerveau a également été étudiée. La pathologie de tous les organes vitaux tels que le rein, le foie et l'intestin a été analysée. En conclusion, l'extrait de feuille de Coccinia grandis possède des activités anti-inflammatoires et analgésiques, un effet antidiabétique et non toxique.
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