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Neurofarmakologia Coccinia grandis - Neuropatia cukrzycowa
Paperback
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ISBN10: 6209831745
ISBN13: 9786209831744
Publisher: Wydawnictwo Nasza Wiedza
Published: Mar 27 2026
Pages: 260
Weight: 0.78
Height: 0.59 Width: 6.00 Depth: 9.00
Language: Polish
ISBN13: 9786209831744
Publisher: Wydawnictwo Nasza Wiedza
Published: Mar 27 2026
Pages: 260
Weight: 0.78
Height: 0.59 Width: 6.00 Depth: 9.00
Language: Polish
Cukrzycowy ból neuropatyczny jest stanem niezwykle wyniszczającym i zazwyczaj trudnym do leczenia. Wyciąg metanolowy z Coccinia grandis zostal przebadany pod kątem dzialania przeciwbólowego i przeciwzapalnego na modelu szczura z neuropatią cukrzycową wywolaną przez STZ. Ostra aktywnośc zapalna zostala zbadana za pomocą testu bólowego Randalla. W nerwie kulszowym i mózgu oznaczono koordynację nocyceptywną, nerwowo-mięśniową, parametry elektrofizjologiczne oraz mediatory stanu zapalnego, takie jak cyklooksygenaza i peroksydaza PG, które przyczyniają się do bólu neuropatycznego. Aktywnośc przeciwbólową badano u szczurów przy użyciu testu gorącej plyty i testu tail-flick. W nerwie kulszowym i mózgu określono zmiany neurochemiczne, takie jak poziom glukozy, fruktozy, sorbitolu i zredukowanego glutationu. Po 3 tygodniach oznaczono również enzymy, takie jak heksokinaza, reduktaza aldozowa, dehydrogenaza sorbitolowa i dehydrogenaza glukozo-6-fosforanowa. Zbadano również zmiany histopatologiczne nerwu kulszowego i mózgu. Przeanalizowano patologię wszystkich ważnych narządów, takich jak nerki, wątroba i jelita. Podsumowując, ekstrakt z liści Coccinia grandis wykazuje dzialanie przeciwzapalne i przeciwbólowe, przeciwcukrzycowe oraz brak efektu toksycznego.
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