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Neuropharmakologie von Coccinia grandis - Diabetische Neuropathie
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ISBN10: 6209821502
ISBN13: 9786209821509
Publisher: Verlag Unser Wissen
Published: Mar 27 2026
Pages: 272
Weight: 0.81
Height: 0.61 Width: 6.00 Depth: 9.00
Language: German
ISBN13: 9786209821509
Publisher: Verlag Unser Wissen
Published: Mar 27 2026
Pages: 272
Weight: 0.81
Height: 0.61 Width: 6.00 Depth: 9.00
Language: German
iabetischer neuropathischer Schmerz ist ein Zustand, der extrem schwächend und in der Regel schwer zu behandeln ist. Ein methanolischer Extrakt aus Coccinia grandis wurde auf seine analgetische und entzündungshemmende Wirkung an einem STZ-induzierten diabetischen neuropathischen Rattenmodell getestet. Die akute entzündliche Aktivität wurde mit dem Randal-Schmerztest untersucht. Nozizeptive, neuromuskuläre Koordination, elektrophysiologische Faktoren sowie Entzündungsmediatoren wie Cyclooxygenase und PG-Peroxidase, die zu neuropathischen Schmerzen beitragen, wurden im Ischiasnerv und im Gehirn bestimmt. Die analgetische Aktivität wurde bei Ratten mittels Hot-Plate- und Tail-Flick-Test untersucht. Neurochemische Veränderungen wie Glukose, Fruktose, Sorbitol und reduziertes Glutathion wurden im Ischiasnerv und im Gehirn bestimmt. Enzyme wie Hexokinase, Aldosereduktase, Sorbitoldehydrogenase und Glukose-6-Phosphat-Dehydrogenase wurden ebenfalls nach 3 Wochen bestimmt. Eine histopathologische Veränderung des Ischiasnervs und des Gehirns wurde ebenfalls untersucht. Die Pathologie aller lebenswichtigen Organe wie Niere, Leber und Darm wurde analysiert. Zusammenfassend lässt sich sagen, dass der Blattextrakt von Coccinia grandis entzündungshemmende, analgetische, antidiabetische und ungiftige Wirkungen besitzt.
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