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Citogenética dos tumores hematológicos malignos
Paperback
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ISBN10: 6208903890
ISBN13: 9786208903893
Publisher: Edicoes Nosso Conhecimento
Published: May 29 2025
Pages: 92
Weight: 0.30
Height: 0.22 Width: 6.00 Depth: 9.00
Language: Portuguese
ISBN13: 9786208903893
Publisher: Edicoes Nosso Conhecimento
Published: May 29 2025
Pages: 92
Weight: 0.30
Height: 0.22 Width: 6.00 Depth: 9.00
Language: Portuguese
Nos tumores malignos hematológicos, podem ser identificadas muitas anomalias cromossómicas, tanto em número como em estrutura. Estas anomalias têm a particularidade de serem adquiridas e de evoluÃrem de forma clonal. Foram identificados vários tipos de anomalias cromossómicas nos tumores sólidos. Para além dos dados citológicos e histológicos, a identificação de uma anomalia genética faz parte integrante do processo de diagnóstico das doenças malignas hematológicas e de certos tumores sólidos. A identificação destas anomalias também desempenha um papel na estratificação do prognóstico e nas escolhas terapêuticas, e permite avaliar a doença residual após o tratamento. As anomalias cromossómicas detectadas em tumores hematológicos malignos são adquiridas (restritas ao clone maligno), clonais, primárias ou secundárias. As anomalias citogenéticas primárias são geralmente especÃficas de uma entidade patológica, enquanto as anomalias secundárias podem ser menos especÃficas; estas últimas reflectem a evolução do clone maligno e atestam a sua instabilidade genética.
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