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Cytogenetyka hematologicznych nowotworów zlośliwych
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ISBN10: 6208903874
ISBN13: 9786208903879
Publisher: Wydawnictwo Nasza Wiedza
Published: May 29 2025
Pages: 92
Weight: 0.30
Height: 0.22 Width: 6.00 Depth: 9.00
Language: Polish
ISBN13: 9786208903879
Publisher: Wydawnictwo Nasza Wiedza
Published: May 29 2025
Pages: 92
Weight: 0.30
Height: 0.22 Width: 6.00 Depth: 9.00
Language: Polish
W hematologicznych nowotworach zlośliwych można zidentyfikowac wiele nieprawidlowości chromosomalnych, zarówno pod względem liczby, jak i struktury. Charakteryzują się one tym, że są nabywane i ewoluują w sposób klonalny. W guzach litych zidentyfikowano różne rodzaje nieprawidlowości chromosomalnych. Oprócz danych cytologicznych i histologicznych, identyfikacja anomalii genetycznej jest integralną częścią procesu diagnostycznego nowotworów hematologicznych i niektórych guzów litych. Identyfikacja tych nieprawidlowości odgrywa również rolę w stratyfikacji prognostycznej i wyborach terapeutycznych oraz umożliwia ocenę choroby resztkowej po leczeniu. Nieprawidlowości chromosomalne wykrywane w hematologicznych nowotworach zlośliwych są nabyte (ograniczone do zlośliwego klonu), klonalne, pierwotne lub wtórne. Pierwotne nieprawidlowości cytogenetyczne są na ogól specyficzne dla jednostki chorobowej, podczas gdy wtórne nieprawidlowości mogą byc mniej specyficzne; te ostatnie odzwierciedlają ewolucję zlośliwego klonu i świadczą o jego niestabilności genetycznej.
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