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Avanços recentes em abordagens bioanalÃticas para a descoberta de biomarcadores
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ISBN10: 6200749183
ISBN13: 9786200749185
Publisher: Edicoes Nosso Conhecimento
Published: Jul 23 2025
Pages: 96
Weight: 0.31
Height: 0.23 Width: 6.00 Depth: 9.00
Language: Portuguese
ISBN13: 9786200749185
Publisher: Edicoes Nosso Conhecimento
Published: Jul 23 2025
Pages: 96
Weight: 0.31
Height: 0.23 Width: 6.00 Depth: 9.00
Language: Portuguese
As infecções por esquistossomose têm sérias implicações para o desenvolvimento socioeconómico em muitos paÃses tropicais. Estas doenças debilitantes e crónicas são endémicas em mais de 70 paÃses, mas as ferramentas de diagnóstico são limitadas e são necessários novos testes para limitar a morbidade e a mortalidade. O desenvolvimento desses testes pode ser facilitado pela identificação de biomarcadores especÃficos da doença que sejam positivos no inÃcio da infecção, que possam distinguir entre infecção aguda e crónica e que possam servir como validação da cura. Este trabalho tem dois objetivos principais: (a) identificar padrões proteómicos especÃficos do estágio durante a infecção precoce (3 semanas), aguda (6 semanas) e crónica (12 semanas) por Schistosoma mansoni num modelo murino; (b) traçar o perfil do soro de humanos infectados por S. mansoni ou S. haematobium e comparar esses padrões com o perfil proteico do soro humano saudável. Para atingir esses objetivos, foram realizadas análises proteômicas em soros de camundongos e humanos usando várias metodologias diferentes de espectrometria de massa (MS).
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