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Progrès récents dans les approches bioanalytiques pour la découverte de biomarqueurs
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ISBN10: 6200749159
ISBN13: 9786200749154
Publisher: Editions Notre Savoir
Published: Jul 23 2025
Pages: 96
Weight: 0.31
Height: 0.23 Width: 6.00 Depth: 9.00
Language: French
ISBN13: 9786200749154
Publisher: Editions Notre Savoir
Published: Jul 23 2025
Pages: 96
Weight: 0.31
Height: 0.23 Width: 6.00 Depth: 9.00
Language: French
Les infections par les schistosomes ont de graves répercussions sur le développement socio-économique de nombreux pays tropicaux. Ces maladies chroniques et invalidantes sont endémiques dans plus de 70 pays, mais les outils de diagnostic sont limités et de nouveaux tests sont nécessaires pour limiter la morbidité et la mortalité. Le développement de tels tests pourrait être facilité par l'identification de biomarqueurs spécifiques à la maladie, qui soient positifs à un stade précoce de l'infection, qui permettent de distinguer les infections aiguës des infections chroniques et qui puissent servir à valider la guérison. Ce travail a deux objectifs principaux: (a) identifier des profils protéomiques spécifiques à chaque stade de l'infection par Schistosoma mansoni chez la souris, à un stade précoce (3 semaines), aigu (6 semaines) et chronique (12 semaines); (b) de profiler le sérum d'humains infectés par S. mansoni ou S. haematobium et de comparer ces profils avec le profil protéique du sérum humain sain. Pour atteindre ces objectifs, des analyses protéomiques ont été réalisées sur des sérums de souris et d'humains à l'aide de plusieurs méthodologies de spectrométrie de masse (MS).
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