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Toksykologiczne dzialanie pestycydu chronionego przez Cynara cardunculus
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ISBN10: 6209712185
ISBN13: 9786209712180
Publisher: Wydawnictwo Nasza Wiedza
Published: Mar 6 2026
Pages: 96
Weight: 0.31
Height: 0.23 Width: 6.00 Depth: 9.00
Language: Polish
ISBN13: 9786209712180
Publisher: Wydawnictwo Nasza Wiedza
Published: Mar 6 2026
Pages: 96
Weight: 0.31
Height: 0.23 Width: 6.00 Depth: 9.00
Language: Polish
Celem tego badania byla ocena ochronnego dzialania mikrosfer Cynara cardunculus, uznanej rośliny leczniczej, na toksycznośc wątroby wywolaną przez środek owadobójczy, deltametrynę. Badania przeprowadzono ex vivo na plynach i tkankach wątroby oraz na mitochondriach wątroby myszy szczepu szwajcarskiego. Karczoch ma duże znaczenie biologiczne ze względu na swoją silną aktywnośc przeciwutleniającą i przeciwrodnikową, zdolnośc do wychwytywania rodników żelaza i nadtlenku wodoru oraz zdolnośc do hamowania lipazy trzustkowej. Toksycznośc wątroby wywolana przez deltametrynę objawia się wyraźnymi oznakami dysfunkcji wątroby. Inkubacja wątroby z tym insektycydem przez godzinę prowadzi do znacznego wzrostu peroksydacji lipidów, a także wzrostu aktywności enzymów antyoksydacyjnych (SOD, CAT, GPx i GSH) w plynie wątrobowym i tkance. Wzrost aktywności enzymów SOD i CAT zaobserwowano również w mitochondriach wątroby, co wskazuje na stres mitochondrialny.
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