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Effets toxicologiques d'un pesticide protection par Cynara cardunculus
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ISBN10: 6209546285
ISBN13: 9786209546280
Publisher: Editions Universitaires Europeennes
Published: Feb 4 2026
Pages: 100
Weight: 0.32
Height: 0.24 Width: 6.00 Depth: 9.00
Language: French
ISBN13: 9786209546280
Publisher: Editions Universitaires Europeennes
Published: Feb 4 2026
Pages: 100
Weight: 0.32
Height: 0.24 Width: 6.00 Depth: 9.00
Language: French
Cette étude a pour objectif d'évaluer l'effet protecteur des microsphères de Cynara cardunculus, plante médicinale reconnue contre la toxicité hépatique induite par un insecticide, la deltaméthrine. Les investigations ont été menées ex vivo sur des liquides et tissus hépatiques, ainsi que sur des mitochondries hépatiques de souris de souche Swiss. L'artichaut présente un intérêt biologique majeur en raison de sa forte activité antioxydante et antiradicalaire, de sa capacité à piéger les radicaux du fer et le peroxyde d'hydrogène, ainsi que de son pouvoir inhibiteur de la lipase pancréatique. La toxicité hépatique induite par la deltaméthrine se manifeste par des signes évidents de dysfonctionnement hépatique. L'incubation du foie avec cet insecticide pendant une heure entraîne une augmentation significative de la peroxydation lipidique, ainsi qu'une élévation des activités des enzymes antioxydantes (SOD, CAT, GPx et GSH) dans le liquide et le tissu hépatiques. Une augmentation des activités enzymatiques de la SOD et de la CAT a également été observée au niveau des mitochondries hépatiques, traduisant un stress mitochondrial.
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