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Neuroscience of Analgesics Textbook 2026-2027: Molecular Targets, Clinical Pharmacology & Precision Prescribing for Pain Medicine Trainees
Paperback
Publisher: Ramon C. Henson
Published: Sep 16 2026
Pages: 362
Weight: 1.85
Height: 0.75 Width: 8.50 Depth: 11.00
Language: English
Connect Neural Mechanisms to Safer, More Precise Pain Care
This clinically focused volume links nociceptor biology, spinal processing, supraspinal networks, receptor pharmacology, and neuroimmune signaling to the choices clinicians make when selecting and monitoring pain therapies. Written for pain medicine, anesthesiology, neurology, pharmacy, and clinical pharmacology trainees, it moves from molecular targets through acute, persistent, cancer-related, and special-population care while keeping function, safety, and stewardship visible.
The Neural Target-to-Therapy Map turns each major mechanism into a repeatable sequence of target, circuit effect, phenotype fit, safety constraint, and decision anchor.
Develop the Clinical Reasoning to
- Trace nociceptive signaling from peripheral transduction to cortical representation - connect drug action with the network level where benefit or toxicity emerges
- Interpret pharmacokinetics, receptor occupancy, tolerance, dependence, and variability - distinguish exposure from meaningful functional response
- Compare nonopioid, opioid, local anesthetic, neuromodulatory, cannabinoid, and adjuvant mechanisms - choose therapies by phenotype instead of habit
- Construct perioperative and acute-care combinations - assign every component a distinct purpose, monitoring plan, and stopping rule
- Match neuropathic, nociplastic, headache, visceral, musculoskeletal, inflammatory, and cancer presentations to plausible targets - make therapeutic trials easier to interpret
- Protect children, pregnant patients, older adults, and people with organ impairment - anticipate altered exposure, vulnerability, and monitoring needs
- Apply compassionate safety and stewardship - recognize interaction burden, respiratory risk, substance-use complexity, and treatment inertia
- Evaluate biomarkers, ion-channel inhibitors, biologics, and other emerging approaches - separate translational promise from clinically established value
Use this book to make every analgesic choice a transparent, monitored, and patient-centered clinical decision.
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