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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Neuronal Network Dynamics in 2D and 3D in Vitro Neuroengineered Systems

Neuronal Network Dynamics in 2D and 3D in Vitro Neuroengineered Systems

Frega, Monica

Hardcover

Series: Springer Theses

Technology & EngineeringBiology

ISBN10: 3319302361
ISBN13: 9783319302362
Publisher: Springer Nature
Published: Mar 10 2016
Pages: 148
Weight: 0.90
Height: 0.44 Width: 6.14 Depth: 9.21
Language: English

The book presents a new, powerful model of neuronal networks, consisting of a three-dimensional neuronal culture in which 3D neuronal networks are coupled to micro-electrode-arrays (MEAs). It discusses the main advantages of the three-dimensional system compared to its two-dimensional counterpart, and shows that the network dynamics, recorded during both spontaneous and stimulated activity, differs between the two models, with the 3D system being better able to emulate the in vivo behaviour of neural networks. The book offers an extensive analysis of the system, from the theoretical background, to its design and applications in neuro-pharmacological studies. Moreover, it includes a concise yet comprehensive introduction to both 2D and 3D neuronal networks coupled to MEAs, and discusses the advantages, limitations and challenges of their applications as cellular and tissue-like in vitro experimental model systems.

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