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Lessons in Bioreactor Scale-Up
Hardcover
Series: Emerging Technologies in Biomanufacturing
Technology & EngineeringChemistry
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ISBN13: 9781041411253
Publisher: CRC Press
Published: Sep 1 2026
Pages: 120
Language: English
Bioreactor scale-up in pharmaceutical science refers to the process of transferring optimal conditions obtained in small-scale, often high-throughput, bioreactors to large-scale bioreactors. It involves considerations such as mass and heat transfer phenomena, tech transfer, and defining and validating operating conditions. The goal is to ensure product quality and facilitate seamless scale conversion. Cell culture bioreactor scale-up is a critical step in the production of biologics such as therapeutic proteins, monoclonal antibodies, and vaccines that are administered to patients suffering from various diseases. It involves translating laboratory discoveries to large-scale industrial applications, while maintaining product quality and cost-effectiveness. Bioreactor scale-up in bioprocessing industry involves transitioning from miniaturized, high-throughput bioreactors to larger bench-scale, pilot- or production-scale bioreactors. It is a pivotal aspect of modern biotechnology, allowing lab discoveries to be developed and applied industrially.
- Bioreactor scale-up is a critical step in the production of biologics such as therapeutic proteins, monoclonal antibodies, and vaccines.
- This valuable process involves translating laboratory discoveries to large-scale industrial applications, while maintaining product quality and cost-effectiveness.
- Bioreactor scale-up in chemistry involves transitioning from miniaturized, high-throughput bioreactors to larger bench-scale and pilot- or production-scale bioreactors.
- A pivotal aspect of modern biotechnology is allowing lab discoveries to be applied industrially.
- Bioreactor scale-up sustainability involves improving fermentation production processes and bioreactor technology to reduce costs, create compelling products, and scale the industry.
- Geometric similarity in bioreactors is crucial for successful scaling-up.
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