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Leishmaniosi e ruolo del ferro
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ISBN10: 6207904311
ISBN13: 9786207904310
Publisher: Edizioni Sapienza
Published: Jul 31 2024
Pages: 56
Weight: 0.21
Height: 0.13 Width: 6.00 Depth: 9.00
Language: Italian
ISBN13: 9786207904310
Publisher: Edizioni Sapienza
Published: Jul 31 2024
Pages: 56
Weight: 0.21
Height: 0.13 Width: 6.00 Depth: 9.00
Language: Italian
I parassiti protozoi unicellulari cinetoplastidi del genere Leishmania sono gli agenti causali di complesse malattie trascurate chiamate leishmaniosi e continuano a rappresentare un importante problema sanitario a livello globale. Il capitolo 1 fornisce una breve panoramica sulla leishmaniosi e illustra il numero di farmaci disponibili per il trattamento, nonché le possibili vie mirate nel parassita Leishmania. Lo scopo del capitolo 2 è quello di fornire un aggiornamento sulle attuali conoscenze relative all'acquisizione e all'utilizzo del ferro da parte delle specie di Leishmania. Per la sopravvivenza e la virulenza del parassita, il ferro come ione metallico svolge un ruolo cruciale in molti aspetti del metabolismo cellulare come cofattore di diversi enzimi. L'acquisizione del ferro è essenziale per la sopravvivenza dei parassiti. Poiché il ferro svolge un ruolo centrale nella risposta dell'ospite e nel metabolismo del parassita, una comprensione completa del metabolismo del ferro è utile per identificare potenziali opportunità terapeutiche contro la leishmaniosi.
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