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Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics

Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics

Paperback

Technology & EngineeringBiologyChemistry

ISBN10: 3662508079
ISBN13: 9783662508077
Publisher: Springer
Published: Sep 3 2016
Pages: 746
Weight: 2.34
Height: 1.54 Width: 6.14 Depth: 9.21
Language: English
Brief historical account of HBOC development.- Physiology of respiration.- Oxygen transport to tissues.- Pathophysiology of acute anemia.- Global blood safety and need for safe blood supply.- Blood transfusion and its limitations.- Scientific basis and design of HBOCs.- HBOCs: a regulatory perspective.- Current HBOC products in development.- Clinical indications and clinical trials of HBOCs.- HBOCs and adverse events observed in clinical trials.- HBOC-mediated vasoactivity and hypertension.- HBOC and oxygen and nitrogen radical mediated toxicity.- HBOCs and clinical laboratory interference.- Animal models for HBOC studies.- New emerging Technologies for universal RBCs.- Future prospects.

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