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From Globular Proteins to Amyloids
Paperback
Series: Commonwealth and International Library
Business GeneralMedical ReferenceBiology
ISBN13: 9780081029817
Publisher: Elsevier
Published: Oct 2 2019
Pages: 278
Weight: 0.83
Height: 0.58 Width: 6.00 Depth: 9.00
Language: English
From Globular Proteins to Amyloids proposes a model and mechanism for explaining protein misfolding. Concepts presented are based on a model originally intended to show how proteins attain their native conformations. This model is quantitative in nature and founded upon arguments derived from information theory. It facilitates prediction and simulation of the amyloid fibrillation process, also identifying the progressive changes that occur in native proteins that lead to the emergence of amyloid aggregations.
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