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Hypertension et maladies apparentées
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ISBN10: 6207342712
ISBN13: 9786207342716
Publisher: Editions Notre Savoir
Published: Apr 1 2024
Pages: 72
Weight: 0.26
Height: 0.17 Width: 6.00 Depth: 9.00
Language: French
ISBN13: 9786207342716
Publisher: Editions Notre Savoir
Published: Apr 1 2024
Pages: 72
Weight: 0.26
Height: 0.17 Width: 6.00 Depth: 9.00
Language: French
L'hypertension artérielle (HT) et les maladies connexes telles que l'insuffisance rénale chronique (IRC) ont en commun le fait que l'une de leurs principales causes est l'augmentation du stress oxydatif, qui accroît à son tour la gravité de la maladie et l'exacerbation des symptômes. Les molécules réactives produites par le stress oxydatif, en plus de causer des dommages aux tissus par l'oxydation de biomolécules telles que l'ADN, les lipides, les protéines et les sucres, conduisent à la formation de médiateurs ayant un puissant effet inflammatoire. L'objectif de cette étude était d'examiner certains marqueurs du stress oxydatif chez des patients souffrant d'hypertension (HT) et d'HT avec une maladie rénale chronique, en plus de certains paramètres biochimiques liés à ces maladies. Cette étude a porté sur 84 sujets masculins âgés de 25 à 65 ans, également répartis en trois groupes, le premier et le deuxième appartenant respectivement aux patients souffrant d'hypertension et d'hypertension artérielle avec IRC de l'hôpital universitaire d'Al-Yarmouk, tandis que le troisième comprend 28 sujets apparemment sains, considérés comme groupe témoin. Pour chaque sujet des trois groupes, les marqueurs et paramètres suivants ont été évalués: 4-hydroxy-2-nonenl (4HNE), synthase d'oxyde nitrique induite (iNOS), albumine, urée, créatinine et protéines sériques totales.
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