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Clinical Immunology: From Basic Principles to Inborn Errors, a Case-Based Guide

Clinical Immunology: From Basic Principles to Inborn Errors, a Case-Based Guide

Paperback

Medical Reference

PREORDER - Expected ship date February 24, 2027

ISBN10: 3032433622
ISBN13: 9783032433626
Publisher: Springer
Published: Feb 24 2027
Language: English

Immunology underpins many specialties, yet immune disorders remain underrecognized by frontline clinicians. Antibody deficiencies are a striking example: antibody deficiencies--including specific antibody deficiency--are found among patients with chronic rhinosinusitis, but many receive only symptomatic treatment without an appropriate immunological evaluation. Some undergo repeated procedures with limited benefit, only to later discover an underlying immune disorder that could have been addressed through targeted, disease-modifying therapy. In addition to these common conditions, rare inborn errors of immunity often present with ordinary clinical complaints, including recurrent infections or subtle autoimmune manifestations affecting the gastrointestinal, neurological, and dermatological systems. Many patients first present with non-infectious features rather than infection, making diagnosis challenging. Understanding the pathophysiology of both common and rare immune defects is therefore essential for clinicians seeking the root causes of complex presentations.

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