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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Three-Dimensional in Vitro Model for Human Prostate Cancer Metastasis to Bone: The Impact of BMP-2 on Metastasis.

Three-Dimensional in Vitro Model for Human Prostate Cancer Metastasis to Bone: The Impact of BMP-2 on Metastasis.

Kwon, Heenam

Paperback

Technology & Engineering

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ISBN10: 1243410795
ISBN13: 9781243410795
Publisher: Proquest Umi Dissertation Pub
Pages: 54
Weight: 0.28
Height: 0.14 Width: 7.99 Depth: 10.00
Language: English
Although prostate cancer cases and deaths have increased for years, the mechanisms involved in prostate cancer metastasis to bone remain poorly understood. To address an effective and relevant in vitro model for the study of prostate cancer bone metastases, we established a 3D in vitro system using 3D aqueous-based silk scaffolds. Further, the role of BMP-2 on the progression of prostate cancer has been investigated using this 3D functional tissue system. The migration of prostate cancer cells (PC3) was determined in the presence or absence of BMP-2. The results suggest that BMP-2 stimulates the migration of PC3 cells. These data also support that the in vitro system is relevant to mimic prostate cancer metastasis in the presence of BMP-2. The 3D in vitro system can be further developed so that it can be utilized as an in vitro model for further studies of prostate cancer metastasis and development of new drugs and therapies.

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