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Treponema denticola
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ISBN10: 6630139607
ISBN13: 9786630139600
Publisher: Verlag Unser Wissen
Published: Sep 28 2026
Pages: 80
Weight: 0.26
Height: 0.19 Width: 6.00 Depth: 9.00
Language: German
ISBN13: 9786630139600
Publisher: Verlag Unser Wissen
Published: Sep 28 2026
Pages: 80
Weight: 0.26
Height: 0.19 Width: 6.00 Depth: 9.00
Language: German
Treponema denticola ist eine im Mundraum vorkommende Spirochäte, die in engem Zusammenhang mit Parodontalerkrankungen steht, insbesondere bei Erwachsenen mit schweren oder chronischen Formen. Im Vergleich zu gesunden Personen wird sie in tiefen Parodontaltaschen von Patienten mit schwerer Erkrankung durchweg in höheren Konzentrationen nachgewiesen, was einen frühen Hinweis auf einen kausalen Zusammenhang liefert. Es handelt sich um einen obligat anaeroben Erreger, der häufig gemeinsam mit Porphyromonas gingivalis vorkommt, was auf eine metabolische Symbiose zwischen den beiden Organismen hindeutet. Strukturell ermöglichen die flexible Zellwand und die inneren Flagellen von T. denticola die Anhaftung an verschiedene Oberflächen - Glykoproteine, Hydroxylapatit, Fibroblasten und Epithelzellen - sowie das Eindringen in das Wirtsgewebe. Es wurde zudem mit Atherosklerose in Verbindung gebracht, kann über längere Zeiträume in Wirtszellen überleben und wandelt Glutathion in Schwefelwasserstoff um, wodurch Gewebe geschädigt und die Abwehrkräfte des Wirts gestört werden. Es kann die Genexpression und die DNA-Methylierung in parodontalen Zellen verändern und wird neben P. gingivalis und Tannerella forsythia zu den Bakterien des Red Complex gezählt. Zu seinen wichtigsten Virulenzfaktoren zählen der Dentilisin-Protease-Komplex (gebildet durch die Gene prcA, prcB und prtP), eine chymotrypsinähnliche Proteaseaktivität sowie Cystalysin.
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